Performance comparison between NG-motif, NGOME and our structure-based methods.
figureposted on 21.07.2017, 17:37 by Lei Jia, Yaxiong Sun
NG-motif and NGOME prediction performances were represented by plotting the TPR v.s. FPR points (red triangle for NG-motif and blue square for NGOME) on the ROC of the RF method (purple line).
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3 D structure-based propertiesdata sets194 Asn residuesforest modelcauses over-engineeringdrug discovery processProtein asparagine deamidation predictionprediction toolshotspot residuestest datadeamidation casedeamidation half-lifeNG motifSequence-based prediction methodsequence-based methodmethods Chemical stabilityprotein therapeuticsstructure-based prediction modelsprediction methodacid residuesacid asparaginedihedral anglesprediction modelsdeamidated residues25 proteinsdeamidated proteinschemical modificationscrystal structuresprotein hotspot predictionstrain prediction modelsdeamidation evaluation processnon-deamidated residues