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Peptidoglycan–polysaccharide (PG-PS)-induced polyarthritis is attenuated in CD14 knockout animals: gross observation score

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posted on 31.12.2011, 04:37 by Xiangli Li, Blair U Bradford, Frederick Dalldorf, Sanna M Goyert, Stephen A Stimpson, Ronald G Thurman, Sergei S Makarov

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Taken from "CD14 mediates the innate immune responses to arthritopathogenic peptidoglycan–polysaccharide complexes of Gram-positive bacterial cell walls"

Arthritis Research & Therapy 2004;6(3):R273-R281.

Published online 27 Apr 2004


Copyright © 2004 Li et al.; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.

Acute PG-PS polyarthritis was induced by intravenous injection of PG-PS (3 mg/kg). The arthritis index was scored as described in the Materials and methods section. Each point represents a mean ± standard error of the mean in 16–19 animals. The significance of the difference between the groups was evaluated by Mann–Whitney rank sum test. *< 0.05.