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Pathology.

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posted on 2019-10-03, 17:30 authored by David J. Titus, Timothy Johnstone, Nathan H. Johnson, Sidney H. London, Meghana Chapalamadugu, Derk Hogenkamp, Kelvin W. Gee, Coleen M. Atkins

Atrophy levels of the cortex and hippocampus. A) Representative 3-dimensional visualizations of brains reconstructed from contours of the ipsilateral (Ipsi) and contralateral (Contra) cortex and hippocampus between bregma levels -3.3 to -6.8 mm. B) Representative H&E plus Luxol fast blue-stained sections at bregma level -3.0 mm. Cortical atrophy was similar between TBI+Vehicle and TBI+AVL-3288 animals. Hippocampal atrophy was modestly reduced in TBI+AVL-3288 animals. Scale bar 1 mm. C) Quantification of atrophy of the ipsilateral parietal cortex. ***p<0.001 vs. Sham, two-way ANOVA with Tukey’s HSD post-hoc test. D) Quantification of atrophy of the ipsilateral hippocampus. ***p<0.001 vs. Sham+Vehicle, Sham+AVL-3288, TBI+AVL-3288, two-way ANOVA with Tukey’s HSD post-hoc test. Mean ± SEM, n = 10 Sham+Vehicle, n = 8 Sham+AVL-3288, n = 11 TBI+Vehicle, n = 11 TBI+AVL-3288.

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