ppat.1010378.g007.tif (298.54 kB)
Download fileP2X1 is strongly expressed on CD73+CD8+ T cells and its inhibition partially restores the potential effects of ATP.
figure
posted on 2022-03-24, 18:38 authored by Shima Shahbaz, Isobel Okoye, Gregg Blevins, Shokrollah Elahi(A) Representative histogram plots, and (B) cumulative data showing P2X1 expression in CD73-/CD73+ CD8+ T cells. (C) Representative histogram plots, and (D) cumulative data of CD73 expression with/without treatment with ATP (25 μM) and PPAD (20 μM) for 48 hr. Statistical analysis determined by the Mann-Whitney U-test (B), Wilcoxon matched-pairs test (D) with significance indicated. Each dot represents results from a study subject.
History
Usage metrics
Read the peer-reviewed publication
Keywords
sup >+</ supmarkedly lower amongdiv >< pinfected individuals upregulatesinfected individuals includingdeveloping ms consideringchronic viral infectionsart ), artcd73 via atpinfected individualsviral infectionsα4β7 integrinwell definedvitro </upon globalterm nonspecific stimulationsignificant upregulationresults mayreduced riskprotein levelsperipheral bloodpart explainobservations implynovel mechanismmultiple sclerosismigratory advantageinhibitory receptorsinduced upregulationhoming receptorselevated levelsdisease relapsecytolytic moleculescerebrospinal fluidscell surfacecell subsetscell entrycd73 workscd73 mrnaantiretroviral therapy