P2X1 is strongly expressed on CD73+CD8+ T cells and its inhibition partially restores the potential effects of ATP.
figureposted on 2022-03-24, 18:38 authored by Shima Shahbaz, Isobel Okoye, Gregg Blevins, Shokrollah Elahi
(A) Representative histogram plots, and (B) cumulative data showing P2X1 expression in CD73-/CD73+ CD8+ T cells. (C) Representative histogram plots, and (D) cumulative data of CD73 expression with/without treatment with ATP (25 μM) and PPAD (20 μM) for 48 hr. Statistical analysis determined by the Mann-Whitney U-test (B), Wilcoxon matched-pairs test (D) with significance indicated. Each dot represents results from a study subject.
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