Overview of structural transitions facilitated by NLRP1/3/Nlrc4^NACHT models in response to ATP.

<p>(A) Superimposed view of open-close state of Nlrc4^NACHT domain; the inactive/closed structure is displayed in gray cartoon and the active/open state structure is presented in yellow cartoon; the hinge region is marked red circle. (B) Comparative view backbone RMSD and Rg of ATP-Mg²⁺ bound NACHT domains in monomeric and dimeric condition. (C) Superimposed view of NLRP/Nlrc4^NACHT models showed structural transitions (pre-MD structures are presented in grey cartoon and post MD structure in colored cartoon).</p>