Overall study design.
Individuals presenting with respiratory symptoms (n = 1,545) were recruited at a TB primary care reference center in Brazil. In two consecutive visits (1–3 days apart), all individuals were screened for diabetes / glucose metabolism disorder in the clinical interview and with laboratory tests (glycated hemoglobin, HbA1c; oral glucose tolerance test, OGTT; fasting glucose levels). Individuals were simultaneously tested for pulmonary TB by identification of acid-fast bacilli (AFB) in sputum smears and positive sputum culture for Mycobacterium tuberculosis. Details of the study design and patient population are described in Methods.