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OVA-Induced esophageal epithelial TSLP induction is dependent upon NF-kB signaling and inhibited by budesonide in vitro.

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posted on 18.03.2016, 23:25 by Prasanna M. Chandramouleeswaran, Dawen Shen, Anna J. Lee, Alain Benitez, Kara Dods, Fiona Gambanga, Benjamin J. Wilkins, Jamie Merves, Yuliana Noah, Sarit Toltzis, Jennifer H. Yearley, Jonathan M. Spergel, Hiroshi Nakagawa, Rene deWaal Malefyt, Amanda B. Muir, Mei-Lun Wang

A) differentiated EPC2-hTERT cells were pre-incubated with Bay-11 for 1hr prior to stimulation with OVA. TSLP in culture supernatant was assayed after 24 hrs. B) Differentiated EPC2-hTERT cells were stimulated with Ova in the presence or absence of budesonide (1uM) or DMSO (vehicle) for 24hrs.TSLP in culture supernatant was assayed using ELISA. ***p<0.001, ****p<0.0001, NS = not significant.

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