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Non-hematopoietic IFN-γ response results in decrease expression of hepatic CXCR3 on T lymphocytes.

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posted on 07.06.2022, 17:29 by Tamir Diamond, Thomas N. Burn, Mailyn A. Nishiguchi, Danielle Minichino, Julie Chase, Niansheng Chu, Portia A. Kreiger, Edward M. Behrens

Quantitative assessment of CXCR3+ expression by mean fluorescence intensity (MFI) in T cell population (B220-, CD90.2+)- (A) CD8+ Teff (B220-, CD90.2+, CD8+ CD44hi CD62Llo), (B) CD4+ cells (B220-, CD90.2+, CD4+,CD8-), and (C) inflammatory monocytes (iMonos) (B220-, CD90.2-, Ly6G-, CD11b+, Ly6C+) (D) Absolute numbers of CXCR3+ iMonos in liver parenchyma. (E) Representative CXCR3+ histogram showing decreased expression of surface CXCR3 in Teff population in mice with IFNgR+/+ liver compared to mice with livers deficient in IFNgR. All data was analyzed using 2-way ANOVA with p values denoted in box embedded in the graphs, medians are depicted in the horizontal line. Symbols denote individual mice.