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Neutralizing activity of KNIH90-F1.

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posted on 08.05.2020, 17:30 by Jang-Hoon Choi, Hye-Min Woo, Tae-young Lee, So-young Lee, Sang-Mu Shim, Woo-Jung Park, Jeong-Sun Yang, Joo Ae Kim, Mi-Ran Yun, Dae-Won Kim, Sung Soon Kim, Yi Zhang, Wei Shi, Lingshu Wang, Barney S. Graham, John R. Mascola, Nanshuang Wang, Jason S. McLellan, Joo-Yeon Lee, Hansaem Lee

Neutralization potency of the RBD-specific mAb KNIH90-F1 was evaluated by a PRNT assay using low mAb concentrations (0.00025–0.25 μg/ml). Percent inhibition by the mAb was determined by comparison with untreated cells (A). The IC50 value was determined by nonlinear regression curve fitting (B). Each experiment was performed in triplicate, and data represent the mean of each experiment with standard errors.