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Neutralization of endogenous TGF-β abrogated TCR-induced Foxp3 expression

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posted on 31.12.2011, 10:33 by Shoba Amarnath, Li Dong, Jun Li, Yuntao Wu, Wanjun Chen

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Taken from "Endogenous TGF-β activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1-infected human CD4CD25T cells"

http://www.retrovirology.com/content/4/1/57

Retrovirology 2007;4():57-57.

Published online 9 Aug 2007

PMCID:PMC2096626.

. Western blot analysis of Foxp3 protein in cultured CD4CD25T cells with indicated reagents (72 hrs). . FACS analysis of intracellular Foxp3 protein cultured with TCR and CD28 in the presence of anti-TGF-β1,2,3 (αTGF-β) or control (mIgG1) antibodies (72 hr). The data are shown for a representative donor. The values are presented as the percentage of CD25Foxp3T cells. . CD25Foxp3T cells (%) in the TCR- and CD28-stimulated CD4CD25T cells in the absence (-) or presence of anti-TGF-β1,2,3 antibody (αTGF-β) at days 3 and 5. Each symbol represents one donor.

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