(a) Pharmacological network structure by intervention class. (b) Psychological network structure by intervention class. Notes: The size of the width of each edge (line) is based on the number of direct comparisons between the 2 connected interventions. The shaded area indicates a “closed” loop (i.e., there is at least 1 study that compares one alternative intervention to an intervention with another alternative to that intervention), allowing the comparison of effect estimates from direct evidence with effect estimates from indirect evidence. AAP, atypical antipsychotic; MRI, monoamine reuptake inhibitor; nAChR, nonselective noncompetitive antagonists of the nicotinic acetylcholine receptor; NRI, norepinephrine reuptake inhibitor; SARI, serotonin antagonist and reuptake inhibitor; SSRI, selective serotonin reuptake inhibitor; TCA, tricyclic antidepressant; TeCA, tetracyclic antidepressant.