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Network analysis using STRING.

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posted on 25.04.2017, 18:27 by Gemma Navarro, Eva Martínez-Pinilla, Alejandro Sánchez-Melgar, Raquel Ortiz, Véronique Noé, Mairena Martín, Carlos Ciudad, Rafael Franco

The list of differentially expressed genes in neocortex after RSV diet was subjected to Network analysis using the STRING software as described in Methods. Square interaction score was set at medium confidence (0.4; scores range from highest, 0.9, to low, 0.15, confidence). Other selected parameters were: average node degree: 1.12, local clustering coefficient: 0.32 and active interaction sources including: text mining, experiments, databases, co-expression, neighborhood, gene fusion and co-occurrence. Moreover, no restrictions were forced in the number of interactions to show. Overexpressed genes are shown within red rectangles. The colors of the edges represent the different types of protein associations, either from known or predicted interactions: from curated databases (blue), experimentally determined (magenta), text mining (green) and co-expression (black).