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Navigation preference correlates with the place field assembly distribution.

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posted on 12.09.2017, 17:25 by Omar Mamad, Lars Stumpp, Harold M. McNamara, Charu Ramakrishnan, Karl Deisseroth, Richard B. Reilly, Marian Tsanov

(A) Spatial distribution of the spikes (colored dots) from the reward loop cells (represented by different colors) recorded from 3 preference group animals and (B) from 3 nonpreference group animals. The straight red line denotes the weighted spatial population vector (SPV) between the southwest (SW) corner at 0° and the northeast (NE) corner at 90°. (C) Spatial distribution from all cells recorded from the same animals from the preference and (D) nonpreference groups, respectively. (E) Weighted SPV (left) for the preference group (n = 10 rats) and the nonpreference group (n = 10 rats), 2-tailed independent t test, t(18) = −6.116, ***p < 0.001; and averaged SPV (right), 2-tailed independent t test, t(18) = −7.283, ***p < 0.001, for reward loop cells. Error bars, mean ± SEM. (F) Weighted SPV (left), 2-tailed independent t test; t(18) = −5.048, ***p < 0.001; and averaged SPV (right), 2-tailed independent t test, t(18) = −5.208, **p = 0.006, for all cells. Error bars, mean ± SEM. (G) Comparison of the weighted SPV (left), n = 10, paired t test; t(9) = 5.043, ***p < 0.001; and averaged SPV (right), n = 10, paired t test; t(9) = 4.331, **p = 0.002 between the reward loop cells and all cells for the preference group. (H) Comparison of the weighted SPV (left), n = 10, paired t test; t(9) = −1.823, p = 0.102; and averaged SPV (right), n = 10, paired t test; t(9) = −1.740, p = 0.116 between the reward loop cells and all cells for the nonpreference group. (I) Correlation between the SW/NE passes ratio and the weighted SPV of the reward loop cells (left), n = 20 rats, Pearson’s r = −0.92, p < 0.001; and all cells (right), n = 20, Pearson’s r = −0.90, p < 0.001. (J) Correlation between the SW/NE passes ratio and the averaged SPV of the reward loop cells (left), n = 20, Pearson’s r = −0.91, p < 0.001; and all cells (right), n = 20, Pearson’s r = −0.75, p < 0.001. Files dataset is available at Figshare public repository in Tsanov 2016 data / Continuous T-maze folder https://figshare.com/s/b86a9a111353ba04bd32 and Tsanov 2017 data / Continuous T-maze CA1 folder https://figshare.com/s/5c5ba9b2811f3d7b7696.

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