NO increases HA production.
figureposted on 02.07.2018, 17:39 authored by Alana K. Majors, Ritu Chakravarti, Lisa M. Ruple, Rachel Leahy, Dennis J. Stuehr, Mark Lauer, Serpil C. Erzurum, Allison Janocha, Mark A. Aronica
SMCs were treated with 500 μM NOC-18 for 6 h. Conditioned medium was collected and HA was quantified with a solid phase binding assay. Data represent the mean +/- S.D. n = 6, P < 0.0001.
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HA cablesguanylate cyclasecable-like HARAW cellsairway epithelial cellsnon-resolving airway inflammationdonors resultsNO-induced productionextracellular matrixmurine macrophagescause changesairway inflammationcable-like structuresNitric oxidehyaluronan depositionairway reactivitynon-immune cellsleukocyte-binding HAnitric oxidemuscle cellscell interactionsNO-treated SMC culturesmuscle cells Asthma