NOS1 deficiency affects several pathways related to macrophage polarization towards M1 after 2 h of LPS stimulation.

Pathway analysis showing the major pathways affected by the downregulation (green) or upregulation (red) of genes by NOS1 knockout in WT macrophages alone (A) and NOS1^−/− macrophages (B) in response to 2 h of LPS treatment. Y-axis displays the number of genes implicated in each pathway.