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NOS1 deficiency affects several pathways related to macrophage polarization towards M1 after 2 h of LPS stimulation.

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posted on 2021-09-29, 17:30 authored by Pingan Chang, Hao Gao, Quan Sun, Xiaohong He, Feifei Huang
<p>Pathway analysis showing the major pathways affected by the downregulation (green) or upregulation (red) of genes by NOS1 knockout in WT macrophages alone (A) and <i>NOS1</i><sup><b><i>−/−</i></b></sup> macrophages (B) in response to 2 h of LPS treatment. Y-axis displays the number of genes implicated in each pathway.</p>

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    th2 cell differentiationreveal novel insightspolarized macrophages stimulatedknockout mouse macrophagesdistinct biological functionsbiological processes related8 h post2 h posttime quantitative pcrmajor pathways affectedmain pathways affectedlonger stimulation timedifferentially expressed genesm2 macrophage polarizationm1 macrophage polarizationdiv >< pampk signaling pathwayaffected genessignaling pathwayfirst timeresponsive genesvarious stimulitranscriptome analysisnos1 signalinglike receptorearly stagedifferent stagesclassically activatedalternatively activated

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