Positions of the MSM mutations in the slow/β-cardiac MyHC rod domain.
The globular head domain is shown in red. (A) The neck domain is shown in yellow and the C-terminal LMM segment of the rod domain is shown in orange. The heptad repeat motif forms the structural basis for coiled-coil dimer of the β-MyHC. (B) The positions of slow/β-cardiac MyHC mutations associated with MSM in the heptad repeat motif are indicated. (C) Differentiated human myotubes stained with MyHC show clear A-bands (white bracket).