pone.0170613.s001.tif (299.73 kB)

Positions of the MSM mutations in the slow/β-cardiac MyHC rod domain.

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posted on 26.01.2017 by Martin Dahl-Halvarsson, Malgorzata Pokrzywa, Manish Rauthan, Marc Pilon, Homa Tajsharghi

The globular head domain is shown in red. (A) The neck domain is shown in yellow and the C-terminal LMM segment of the rod domain is shown in orange. The heptad repeat motif forms the structural basis for coiled-coil dimer of the β-MyHC. (B) The positions of slow/β-cardiac MyHC mutations associated with MSM in the heptad repeat motif are indicated. (C) Differentiated human myotubes stained with MyHC show clear A-bands (white bracket).