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MyomiRs and certain miRNAs from DLK1-DIO3 locus constitute a fraction of normomiRs.

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posted on 2022-04-27, 17:27 authored by Sharif Moradi, Aryan Kamal, Hamidreza Aboulkheyr Es, Farnoosh Farhadi, Marzieh Ebrahimi, Hamidreza Chitsaz, Ali Sharifi-Zarchi, Hossein Baharvand

(a). KEGG analysis of genes predicted to be targeted by myomiRs. The gene targets of myomiRs were predicted using TargetScan and the GO analysis was performed using the KEGG feature of Enrichr. (b). GO analysis of genes predicted by TargetScan to be targeted by miR-381, miR-411, and miR-1247. These miRNAs belong to the DLK1-DIO3 locus-embedded miRNA cluster.

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Pan-cancer analysis of microRNA expression profiles highlights microRNAs enriched in normal body cells as effective suppressors of multiple tumor types: A study based on TCGA database
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r programming ).predicted gene targetsobtained using targetscanmeans ± semcell viability assaystargeting multiple typesconsidered statistically significantnormal body cellscancer genome atlasxlink "> micrornasmultiple cancer typesmultiple tumor types’ normomirs ’)enriched mirnas (<corresponding tumour tissues14 cancer typesmirna sequencing data14 typesxlink ">normal tissuesvarious typesstudent ’locus (<normal samplescancer strategycancer setcancer projectcancer analysissuppressive mirnassuppressing mirnasstudy basedsmall setsignificant differencesreplacement therapiespotent inhibitionpotent antimirna expressionlab experimentsgo termsfunctionally analysefrequently deregulatedflow cytometryeffective suppressorscccgu motifblock oncomirsantisense oligonucleotides

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