Multiple sequence analysis of tubulin 1SA0 and human β-tubulin isotypes.
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posted on 2016-05-26, 20:39 authored by Bajarang Vasant Kumbhar, Anubhaw Borogaon, Dulal Panda, Ambarish KunwarThe isotype βIII shows change of Ala315 to Thr, Cys239 to Ser, and Thr351-to Val, Isotype βII change of Val316 to Ile at the colchicine binding pocket. Region of changed residues at colchicine binding pocket are shown in red color.
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binding affinitiesTubulin isotypes αβ IIsequence analysis studytubulin isotypes showMM-GBSAbinding free-energy calculationdynamics simulations results showcolchicine binding pocketDifferential Binding Affinitiesbinding affinitydynamics simulation analysisresidue variationsDAMA-colchicineIIIIVMolecular Dynamics Simulations Tubulin isotypesbinding free-energy
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