Morphological analysis of treated and untreated parasites.
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posted on 2017-06-06, 17:30 authored by Anjali Kumari, Krishn Pratap Singh, Abhishek Mandal, Ranjeet Kumar Paswan, Preeti Sinha, Pradeep Das, Vahab Ali, Sanjiva Bimal, Chandra Shekhar LalParasites were cultivated in M199 medium supplemented with 10% fetal bovine serum in the presence or absence of TPEN or ZnSO4 for 24 hr. Cell morphology was analysed at 400X by optical microscopy as described in material and method section. Arrow indicates altered morphological forms in L. donovani promastigotes.
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TPEN-induced Zn depletionplasma membrane integrityobligate intracellular parasitesurvivalLeishmania donovani LeishmaniasisROS-mediated caspase-independent mitochondrial dysfunctioncontrol Leishmanial growthhostpromastigoteLeishmania parasites scavengenovel drug targetsintracellular Zn depletionZinc-specific chelator Napoptosis-like cell deathIntracellular zinc flux causes reactive oxygen speciesZnSO 4DNA fragmentation analysis
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