ppat.1009950.g008.tif (137.6 kB)

Model summarizing the regulatory role of miR-24 in HSV1 induced STING signaling.

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posted on 2021-09-30, 17:25 authored by Nikhil Sharma, Chenyao Wang, Patricia Kessler, Ganes C. Sen

The model depicts the regulation of STING protein levels by HSV1 induced miR-24 expression which inhibits STING signaling and promotes viral replication. HSV1 infection activates MAPKs which enhance the expression of AOPEP mRNA and miR-23b, miR-27b, miR-24 leading to miR-24 accumulation and targeting of STING signaling. This acts as an immune evasion strategy adopted by the virus to augment its own replication.