Mixed selectivity corresponds to the ability of a neuronal population to encode simultaneously independent sources of information: (A) Firing rate of a representative SUA aligned on the cue (200 ms before the cue onset to 1,000 ms after the cue onset) in exogenous task (blue), endogenous task (green) and memory guided saccade task (red) for preferred (solid line) and non-preferred (dash line) position.

<p>The data were baseline corrected (−500 to −200 ms before cue onset) on individual trial and channel. Gray box corresponds to the delay period during which neuronal activities were analyzed for subplots C and D. <b>(B)</b> Firing rate of a representative SUA (same as in <b>A</b>) aligned on the target (500 ms before the target onset to 500 ms after the target onset). All else as in <b>A</b>. <b>(C)</b> Mean firing rate of the SUA neuronal population in the three tasks aligned on cue presentation (200 ms before the cue onset to 1,000 ms after the cue onset) in the exogenous task (blue), the endogenous task (green) and the memory guided saccade task (red) for preferred (full line) and non-preferred (dash line) position. The data were baseline corrected (−500 to −200 ms before cue onset) on individual trial and channel. Gray box corresponds to the delay period during which neuronal activities were analyzed for subplots C and D. <b>(D)</b> Firing rate of the SUA neuronal population (same as in <b>C</b>) aligned on the target (500 ms before the target onset to 500 ms after the target onset). All else as in <b>C</b>. <b>(E)</b> Venn diagram representing the proportion of cells showing a spatial tuning in each of the three tasks. <b>(F)</b> Pie chart corresponding to the proportion of neurons tuned to only position (red), task (blue) and both (Additive mixed-selectivity; yellow; Mixed-selectivity with interaction; green). Non-selective neurons are plotted in gray. Wilcoxon ranksum test was performed between baseline (−100 to 0 before the cue onset) and time interval (800–900 ms after the cue onset) for each channel and position across trials. A non-parametric 2-Way-ANOVA was performed on selective channels with Bonferroni–Holm correction on spatial and task factor on time interval from 600 to 900 ms after the cue onset (<i>p</i> < 0.01). Data and code to <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3003353#pbio.3003353.s004" target="_blank">S2 Fig</a> can be found at <a href="https://osf.io/z8eh9/" target="_blank">https://osf.io/z8eh9/</a>.</p> <p>(TIFF)</p>