Methylation patterns of CRH promoter copies bound by TATA-binding protein (TBP).
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(A) Binding of TBP to the CRH proximal promoter was determined by ChIP. Significant treatment effects at each promoter region (shown in Fig 1A) are indicated by asterisks (*, P < 0.05, ANOVA with repeated measures, N = 3 placentae; n.d, undetectable ChIP signal). (B) and (C), Methylation patterns of promoter copies bound by TBP in vehicle treated and 8-Br-cAMP-treated cultures, respectively. Arrows (←) on the right indicate patterns compatible with Pol-II binding, while (x) denotes methylation pattern compatible with binding by pCREB as shown in Fig 6B and 6D, respectively. Placenta numbers are on the left; filled circles indicate methylated CpGs and open circles indicate unmethylated CpGs. The positions of CpG Sites are as shown in Fig 1A.