Metal-sensitized caspase-1 knockout female (DTH: Female caspase-1 -/-) mice produce IFN-gamma dominated T-cell responses to implant metal-challenge.
Percentage increase of lymphocyte cytokine production of IFN-gamma or IL-17A/F in response to (A) Ni challenge and (B) Co challenge; calculated using cytokine production to metal(s) vs. respective negative control media cell cytokine production from female metal-DTH BL/6 and Caspase-1 -/- mice. Data represents two independent experiments with n = 4–5 mice/group in each experiment. Data are shown as the mean ± SEM. Statistical significance was determined by unpaired Mann-Whitney test.