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Metabolic capacity of fatty acid oxidation in steatotic and non-steatotic livers during perfusion.

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posted on 24.01.2020, 18:48 authored by Siavash Raigani, Negin Karimian, Viola Huang, Anna M. Zhang, Irene Beijert, Sharon Geerts, Sonal Nagpal, Ehab O. A. Hafiz, Fermin M. Fontan, Mohamed M. Aburawi, Paria Mahboub, James F. Markmann, Robert J. Porte, Korkut Uygun, Martin Yarmush, Heidi Yeh

(a) Carnitine and (b) β-hydroxybutyrate concentration fold change at each hour of perfusion compared to pre-perfusion concentration. (c) Heatmap of fatty acylcarnitine metabolite concentration fold change at each hour of perfusion. Steatotic livers demonstrate upregulation of fatty acid oxidation, with resultant depletion of carnitine and fatty acylcarnitine levels during perfusion, but favor greater ketone synthesis compared to non-steatotic livers. ** indicates P≤0.05, * indicates 0.05