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Metabolic analysis of cellular metabolism in steatotic and non-steatotic livers during perfusion.

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posted on 24.01.2020, 18:48 authored by Siavash Raigani, Negin Karimian, Viola Huang, Anna M. Zhang, Irene Beijert, Sharon Geerts, Sonal Nagpal, Ehab O. A. Hafiz, Fermin M. Fontan, Mohamed M. Aburawi, Paria Mahboub, James F. Markmann, Robert J. Porte, Korkut Uygun, Martin Yarmush, Heidi Yeh

Ratio of metabolite concentration fold change at each hour of perfusion compared to pre-perfusion concentration shown for (a) tricyclic acid cycle, (b) glycolysis, and (c) pentose phosphate pathway. Steatotic livers demonstrate decreased flux through each metabolic pathway. ** indicates P≤0.05, * indicates 0.05