Fig 1.TIF (1.87 MB)
Maximum likelihood phylogeny (PhyML) of unc-29 codon sequence from clade III and clade V nematodes.
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posted on 2016-07-14, 11:49 authored by Thomas B. Duguet, Claude L. Charvet, Sean G. Forrester, Claudia M. Wever, Joseph A. Dent, Cedric Neveu, Robin N. BeechStandard nomenclature indicates the species. Asu: A. suum, Tzc: T. callipaeda, Bma: B. malayi, Llo: L. loa, Dim: D. immitis, Ovo: O. volvulus, Lsi: L. sigmodontis, Avi: A. viteae, Cjp: C. japonica, Cel: C. elegans, Cre, C. remanei, Ctr, C. tropicalis, Cbr, C. briggsae, Pex: P. exspectatus, Ppa: P. pacificus, Hco: H. contortus, Tci: T. circumcincta, Tco: T. colubriformis, Acs: A. costaricensis, Dvi: D. viviparus, Ode: O. dentatum, Aca: A. caninum, Ace: A. ceylenicum, Nbr: N. brasiliensis. Reliable nodes with SH support of more than 0.9 are indicated by a white circle. Nodes corresponding to inferred duplication events are indicated by a yellow circle. doi:10.1016/j.pt.2010.04.003, 10.1093/sysbio/syq010
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gene copiesreceptor assemblyanthelmintic drug targetsreceptors reconstitutedphenotype rescueCaenorhabditis eleganscodon substitution rate analysisacetylcholine receptorssubunits co-expressedRecent DuplicationXenopus oocytesnematodeacetylcholine receptor subunit genesFunctional Divergencenovel drug targetssubunit duplicationfast-synaptic transmissionclade Vgenome dataHaemonchus contortusunc -29acetylcholine receptor subunitacid positions25 speciesreceptor composition changesubunit compositionParasitic Nematode Levamisole-Sensitive Acetylcholine Receptors Helminth parasitesgene duplicationsubunit assemblypentameric levamisole-sensitive acetylcholine receptor50 helminth genome initiative
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