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Matrix metalloproteinases and their inhibitors in human traumatic spinal cord injury-4

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posted on 31.12.2011, 08:00 authored by Armin Buss, Katrin Pech, Byron A Kakulas, Didier Martin, Jean Schoenen, Johannes Noth, Gary A Brook

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Taken from "Matrix metalloproteinases and their inhibitors in human traumatic spinal cord injury"

http://www.biomedcentral.com/1471-2377/7/17

BMC Neurology 2007;7():17-17.

Published online 26 Jun 2007

PMCID:PMC1914362.

ctions.8 days after injury. Double immunofluorescence for CD68 (red) and MMP-1 (green). Almost all microglia/macrophages were MMP-1 positive at the lesion site. 8 months after injury. Double immunofluorescence for GFAP (green) and MMP-1 (red). Large, activated, strongly GFAP-positive astrocytes expressing MMP-1 were observed in the glial scar tissue. 11 days after trauma, MMP-2 immunoreactivity (green) was expressed by CD68 positive microglia/macrophages (red) at the lesion site. 2 days after injury, CD68 positive microglia/macrophages (red) were MMP-9 immunoreactive (green) at the lesion epicentre. 24 days after trauma, dense packing of large, CD68 positive macrophages (red) which also stained for MMP-9 (green) was visible at the lesion epicentre. In the same case, double immunofluorescence with CD68 (red) and MMP-12 (green) showed a nearly identical distribution. Eight months after injury, activated GFAP-positive astrocytes (green) displayed TIMP-3 immunoreactivity (red) in the perilesional scar.

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