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Manhattan plot indicating the associations between DBP and DNA methylation of men of European and South Asian ancestry.

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posted on 2020-01-30, 18:33 authored by Nabila Kazmi, Hannah R. Elliott, Kim Burrows, Therese Tillin, Alun D. Hughes, Nish Chaturvedi, Tom R. Gaunt, Caroline L. Relton

The plot demonstrates the associations between DBP and DNA methylation of European and South Asian men collectively. The model was adjusted for confounders, estimated cell counts and principal components. The uncorrected log10(p-values) are plotted on the y-axis. The blue line is drawn to separate the CpG sites that surpassed p-value<1×10−05, a threshold for a suggestive association and the red line to separate the CpG sites that surpassed the Bonferroni-corrected threshold (p-value<1.24×10−07). The CpG sites that surpassed the Bonferroni-corrected threshold were considered to be associated with the trait.

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