pgph.0002200.g005.tif (596.04 kB)
Malaria prevalence five years after MDA (box plots summarize 100 simulations each) with baseline PfPR2-10 = 1% and importation of 580Y alleles set at 0.1 cases/day.
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posted on 2023-07-26, 17:26 authored by Tran Dang Nguyen, Thu Nguyen-Anh Tran, Daniel M. Parker, Nicholas J. White, Maciej F. BoniThe numbers printed below each plot indicate the number of simulations that reached fewer than 100 malaria cases present in the population (i.e. almost all are imports), which is a proxy for the number of simulations that achieved elimination. Numbers of rounds of MDA are shown by different colors, and four levels of improved treatment access are considered on the x-axis (65% coverage post-MDA to 80% coverage post-MDA). Improved treatment coverage post-MDA increases the chances of local elimination.
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useful therapeutic lifestrong genetic bottleneckingbased stochastic modelplasmodium falciparum malaria cases postantimalarial treatments maysupporting high coverageselection pressure exertedcontinued selection pressuremda using dihydroartemisininmass drug administrationdiv >< presistant parasites mayaccelerated resistance levelsselection pressurehigh levelsresistant parasiteskelch13 antimalarial drugsuniformly highsensitive parasitesresistant genotypestreatment postterm benefitsustained improvementsppq ),mda increasesline therapiesfocal populationfalls short