pone.0247805.g001.tif (393.63 kB)
MALDI-TOF MS spectra of tryptic glycopeptides from the IgG Fc part.
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posted on 2021-02-26, 18:31 authored by Daniel Hirschberg, Bertil Ekman, Jeanette Wahlberg, Eva LandbergAnalysis was performed in the positive reflector-mode using 4-chloro-α-cyanocinnamic acid as matrix. Peptides from IgG2 and IgG3 have identical amino acid sequence, thus assigned IgG2/3. Samples were collected from a normoprolactinaemic healthy individual (a) and a patient with hyperprolactinaemia (b). Symbols denote individual monosaccharides as explained in the figure.
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peptide hormoneprolactin valuesSialic acidperformance anion-exchange chromato...immunoglobulin levelspatient groupamperometric detectionTryptic glycopeptidesmacroprolactinaemic patientsIgG interactionscontrol subjectsIgG 1Protein G Sepharoseflight mass spectrometryimmunoglobulin Gbisecting glycanshyperprolactinaemia Prolactinhaematological analysesliver enzymesgender distributionAltered immunoglobulin G glycosylation
