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M1-like and M2-like macrophage phenotype of alveolar macrophages in T-CNT-exposed mice.

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posted on 2018-10-29, 17:31 authored by Kunihiro Otsuka, Koichi Yamada, Yuhji Taquahashi, Rieko Arakaki, Aya Ushio, Masako Saito, Akiko Yamada, Takaaki Tsunematsu, Yasusei Kudo, Jun Kanno, Naozumi Ishimaru

(A) CD192 (M1) and CD206 (M2) expression of F4/80+CD11b+ macrophages in BALF, spleen, and LNs was detected by flow cytometric analysis. The results are representative of each group. (B) The proportion of CD192+CD206− M1-like macrophages, CD192−CD206+ M2-like macrophages, and CD192+CD206+ macrophages in BALF, spleen, and LNs was measured flow cytometric analysis. Data are presented as the average ± SD of five mice of each group. *p < 0.05, vs controls.

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Long-term polarization of alveolar macrophages to a profibrotic phenotype after inhalation exposure to multi-wall carbon nanotubes
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M 2 polarizationT-CNT exposuremulti-wall carbon nanotubes Background NanomaterialsTaquann-treated multi-walled CNTsprofibroticphenotypeinflammationmatrix metalloprotinase -12. Conclusionsalveolar macrophagesT-CNT-exposed miceinhalationbronchoalveolar lavage fluidfibrotic lesion formation

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