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Loss of clbn leads to ISCs over-proliferation and mitochondrial fragmentation independent of ribosome-associated quality control pathways.

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posted on 15.10.2020, 17:52 authored by Zhaoxia Dai, Dong Li, Xiao Du, Ying Ge, Deborah A. Hursh, Xiaolin Bi

(A-F) The posterior midguts of 15-day-old female flies of control (esg-lacz) (A), clbn KO (B), over-expression of dNOT4 (C), dUPF1 (D), deRF1 (E) and dXRN1 (F) in ECs under clbn KO background were stained with anti-β-gal antibody (green), anti-Prospero antibody (red) and DAPI (blue). (G) Quantification of the number of progenitor cells in flies of control (n = 10), clbn KO (n = 10), over-expression of dNOT4 (n = 10), dUPF1 (n = 10), deRF1 (n = 10) and dXRN1 (n = 10) in ECs under clbn KO background. (H) Quantification of the number of Pros+ cells in flies of control (n = 10), clbn KO (n = 10), over-expression of dNOT4 (n = 10), dUPF1 (n = 10), deRF1 (n = 10) and dXRN1 (n = 10) in ECs under clbn KO background.

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