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LC–MS/MS analysis of 5-, 11-, 12- and 15-HETE levels in WT and t-AUCB-treated WT mouse heart perfusates at baseline (pre-ischemia) and post-ischemia.

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posted on 01.09.2016, 04:33 by Ahmad Hanif, Matthew L. Edin, Darryl C. Zeldin, Christophe Morisseau, Mohammed A. Nayeem

In WT mice, 5-, 11-, 12- and 15-HETE levels decreased post-ischemia compared to baseline, but this was only significant for 5-HETE (A), 11-HETE (B), and 15-HETE (D) (p < 0.05). The same mid-chain HETEs had a decreasing trend post-ischemia compared to baseline in t-AUCB-treated WT mice, but this was not significant (p > 0.05, A-D). Treatment with t-AUCB decreased HETE levels in WT mice, which was significant for 5-HETE (A), 11-HETE (B) and 15-HETE (D) levels at baseline (p < 0.05), and in 11-HETE levels post-ischemia (p < 0.05, B). * p < 0.05 versus baseline WT. # p < 0.05 versus post-ischemia WT. n = 8.

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