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Key transcriptional regulators identified in LUAD vs. BRCA and comparison of CENPA/FOXM1/MYBL2-linked probes in each dataset.

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posted on 14.09.2020, 17:41 by Daniel J. Mullen, Chunli Yan, Diane S. Kang, Beiyun Zhou, Zea Borok, Crystal N. Marconett, Peggy J. Farnham, Ite A. Offringa, Suhn Kyong Rhie

(A) Barplot of the top 12 transcriptional regulators by number of links to activated enhancers identified using TENET 2.0 in LUAD (left) and BRCA (right). (B) Venn diagrams display overlap of probes linked to CENPA, FOXM1, and MYBL2 and (C) all hypomethylated probes in the LUAD vs. BRCA analyses. There is a considerably higher percentage of overlap between all hypomethylated probes than for probes linked only to CENPA, FOXM1, or MYBL2.

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