KEGG Enriched Pathways Network of Aciner CellCarcinoma top 10 genes.svg

This study investigates the mutational landscape of Acinar Cell Carcinoma (ACC), focusing on the top ten most frequently mutated genes and their impact on key pathways using publicly available genomic data from cBioPortal and bioinformatics tools such as Bioconductor in R and Cytoscape.This study leverages data from the Acinar Cell Carcinoma of the Pancreas (JHU, J Pathol 2014) project, which provides whole exome sequencing data of 23 surgically resected pancreatic carcinomas.Using this data, mutation analysis and pathway enrichment were performed and key mutated genes present in ACC were identified, followed by functional pathway enrichment. Thereafter mutation interactions were visualized using Cytoscape. These findings highlight key pathways and mutation patterns, offering insights into driver mutations, co-occurrence and therapeutic targets in ACC. Our approach underscores the importance of pathway interactions in cancer progression, while contributing to the growing body of research on Acinar Cell Carcinoma.