Intravitreal injection of Myo/Nog cells partially preserved visual function after light damage.

Visual function was assessed using the ERG 7 days after light damage. The a-wave and b-wave amplitudes in response to bright flash were normalised to baseline (before light damage) bright flash responses and averaged for each treatment group. Control animals suffered no injection and no light damage. G8+ animals suffered no light damage but were injected with purified G8+ cells and assessed 7 days after injection. LD stands for Light damage. (A) Representative ERG traces from eyes with LD alone, LD eyes injected with PBS (LD/sham) and LD eyes injected with G8+ (LD/G8+). (B) Mean change in a-wave amplitudes for retinas from the 5 experimental groups, from before treatment. Error bars show SEMs. Control rats that did not receive light damage showed no significant change in the a-wave between the two ERG measurements (n = 4). Control rats that did not receive light damage, but were injected with G8+ cells also showed no significant change in the a-wave between the two ERG measurements (n = 3). Visual function, as measured by the a-wave, was significantly improved following light damage with injection of G8+ cells (n = 18) compared to LD alone (n = 18) and LD/sham (n = 18) (LD/G8+: vs. LD ** p < 0.01, vs. LD/Sham * p < 0.05).