Integrated analysis of DEGs in WT and <i>NOS1</i>^−/− macrophages post-LPS stimulation.

<p><b>A and B</b>, Venn diagram showing the total number of genes upregulated (more than 2-fold) and downregulated (less than 0.5-fold) in WT and <i>NOS1</i>^−/− BMDMs treated with LPS for 2 (A) and 8 h (B) compared with untreated cells (0h). Each portion of a Venn diagram displays the number of DEGs in <i>NOS1</i>^−/− BMDMs compared to <i>WT</i> BMDMs. <b>C and D</b>, Histogram showing the number of genes upregulated (red) and downregulated (green) in <i>NOS1</i>^−/− compared with WT BMDMs post 2 and 8 h of LPS stimulation. <b>E and F</b>, Heat map of DEGs in macrophages with 2 and 8 h of LPS stimulation or without LPS stimulation. Each row represents a gene, and each column represents a time point.</p>