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Input data for the polysomy method.

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posted on 13.05.2016, 21:25 authored by Petr Danecek, Shane A. McCarthy, Richard Durbin

Unscaled (A) and scaled (B-D) distributions of BAF values typical for the copy number states 2-4. In (C) we infer that 33% of the cells are aneuploid copy number 3, and in (D) we infer a sample with 20% contamination. The black line is the complete BAF distribution over 0 to 1 of which only part is modelled (shown in red); the green line is the best fit to the red part of the distribution. The model does not include the RR peak and including the AA peak is optional.