Inhibitory effect of farnesol on C. auris biofilms.
figureposted on 2020-05-11, 17:29 authored by Vartika Srivastava, Aijaz Ahmad
CLSM analysis of C. auris strain MRL 5765 biofilms treated with farnesol at different stages of growth and development (4h, 12h and 24h). The image utilizes ConA- Alexa Fluor 488 conjugate and FUN-1 staining, a 63X oil immersion objective with magnification, X2.5. In above images structures shown in green (ConA) represent the fungal cell wall and biofilm matrix; structures in yellow-green (FUN-1) are metabolically inactive and dead cells; structures in orange-red (FUN-1) are the viable cells.
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MICMajor Facilitator SuperfamilyCandida auris strainsbiofilm formationCandida speciesMTT reduction assayintracellular accumulation assaysauris biofilm formationdrug efflux mechanismMDRmMCLSIrhodamine -6-G extracellular effluxfarnesol Candida aurisATP Binding Cassette24 h biofilmcause multidrug resistancebottom microtiter plateAntifungal susceptibility profileefflux pumps