ppat.1010243.s005.tif (802.7 kB)
Inferred avidity, serum IgG concentration, and HI titers by time after transplantation, immunosuppression grade, and cGVHD grade in 43 patients (197 samples in total).
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posted on 2022-01-31, 18:40 authored by Janina Linnik, Mohammedyaseen Syedbasha, Yvonne Hollenstein, Jörg Halter, Adrian Egli, Jörg StellingNote that data show one-dimensional associations, whereas regression analysis was performed with a high-dimensional model simultaneously accounting for time after transplantation, immunosuppression/cGVHD grade, and correcting for sex and age.
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sup >&# 8722provide quantitative insightslarger patient populationsexplains quantitative aspects>&# 961 ;lower baseline aviditiescomplement experimental measurementsneutralizing antibody aviditiesmodel accurately describesmeasured hi titerslinked immunosorbent assaydiv >< pclassical hemagglutination inhibitionneutralizing antibody concentrationhemagglutination inhibitionneutralizing antibodiesinfer aviditiesestablish measurementsavidities inferredvaccinated patientsurea elutionterm protectionstudy demonstratespipetting errorsp model predictedmodel correlatedimportant parametersimmunosuppressive treatmentigg concentrationshi titerhi assayfirst principlesestablishing longdisentangle causesdetection limitbiophysical modellingbiophysical modelbased inferenceapproach requiresagglutination assays70 ],
