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Induction of apoptosis in M14 melanoma cells by statins

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posted on 2011-12-30, 20:00 authored by Sharon A Glynn, Dermot O'Sullivan, Alex J Eustace, Martin Clynes, Norma O'Donovan

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Taken from "The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, simvastatin, lovastatin and mevastatin inhibit proliferation and invasion of melanoma cells"


BMC Cancer 2008;8():9-9.

Published online 16 Jan 2008


M14 cells were exposed to statin treatment for 72 hours. Taxol (0.1 μM) was used as a positive control for apoptosis induction. Apoptosis was measured using an annexin V assay on the Guava EasyCyte, and results presented as % early and late apoptotic cells. (Lova = Lovastatin, Meva = Mevastatin, Simva = Simvastatin). Error bars represent std error of the mean for triplicate experiments. * indicates p < 0.05 using the Student's t-test to compare levels of late apoptosis in statin treated cells versus control.


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