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Increased secretion of TNF-α and IL-6 in IEC6 cells in response to LPS requires KLF5

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posted on 2011-12-31, 05:55 authored by Sengthong Chanchevalap, Mandayam O. Nandan, Beth B. McConnell, Laetitia Charrier, Didier Merlin, Jonathan P. Katz, Vincent W. Yang

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Taken from "Krüppel-like factor 5 is an important mediator for lipopolysaccharide-induced proinflammatory response in intestinal epithelial cells"

Nucleic Acids Research 2006;34(4):1216-1223.

Published online 25 Feb 2006

PMCID:PMC1383625.

© The Author 2006. Published by Oxford University Press. All rights reserved

IEC6 cells were treated with water control (open bars) or 5 µg/ml LPS (filled bars) for the periods of time specified. The amounts of TNF-α () and IL-6 () in the supernatants were determined by ELISA. = 4 in all experiments. * < 0.05 compared to control. Mock-transfected IEC6 cells or IEC6 cells transfected with non-specific (NS) siRNA or KLF5-specific siRNA were treated with water control (open bars) or 5 µg/ml LPS (filled bars) for 48 h. The amounts of TNF-α () and IL-6 () in the supernatants were determined by ELISA. = 4 in all experiments. * < 0.05 compared to control.

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