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Download fileInactivation of thoc1 induced apoptosis in neuromasts.
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posted on 2020-08-10, 17:34 authored by Luping Zhang, Yu Gao, Ru Zhang, Feifei Sun, Cheng Cheng, Fuping Qian, Xuchu Duan, Guanyun Wei, Cheng Sun, Xiuhong Pang, Penghui Chen, Renjie Chai, Tao Yang, Hao Wu, Dong Liu(a) Confocal microscopic imaging analysis of the hair cells in control and thoc1-KO Tg(pou4f3:gap43-GFP) at 3 and 4 dpf. Arrowheads indicate the abnormal hair cells. (b) TUNEL analysis of the neuromasts in control and thoc1-KO embryos at 4 dpf. Green: TUNEL staining. Blue: DAPI staining of the cell nuclei.
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p 53zebrafish hair cellsgenome-wide linkage analysisp 53-mediated hair cell apoptosislate-onset nonsyndromic hearing losshair cell apoptosis Apoptosisp.L 183V varianthearing lossTHOC 1 deficiencyage-related hearing losswild-type THOC 1 mRNAhair cell losscochlear hair cellsnon-syndromic hearing lossTHOC 1 mutations.547CgRNA-Cas 9 systemp 53 inhibitor Pifithrin -αthoc 1 knockoutThoc 1 knockdown zebrafishhair cell numbersThoc 1 deficiency
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