ppat.1010416.s004.TIF (1.38 MB)
Download fileImmunophenotype of HTLV-1p12KO inoculated animals.
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posted on 2022-04-04, 17:32 authored by Ramona Moles, Sarkis Sarkis, Veronica Galli, Maria Omsland, Maria Artesi, Massimiliano Bissa, Katherine McKinnon, Sophia Brown, Vincent Hahaut, Robyn Washington-Parks, Joshua Welsh, David J. Venzon, Anna Gutowska, Melvin N. Doster, Matthew W. Breed, Kristin E. Killoran, Joshua Kramer, Jennifer Jones, Marcin Moniuszko, Anne Van den Broeke, Cynthia A. Pise-Masison, Genoveffa FranchiniMonocyte density. Density plot of CD45+CD3+CD4+, CD45+CD3+CD8+, CD45+CD14+ monocytes, CD45+CD16+ monocytes, CD45+CD20+, CD45+NKG2A+, and CD45+NKG2A+CD16+ cells at baseline, day 0, and weeks 2 and 21 of the animals included in the (A) α-CD8/NK p12KO (B), α-CD8 p12KO, and (C) Clodronate p12KO groups.
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sup >+single point mutationmacrophage depletion resultedincreased cd47 “depleting cell subsetschronic inflammation observedsparing infected cellsengulfed infected cellsmodulating inflammasome activationdiv >< pdecreased monocyte engulfment1 wild typeinnate nk cellsexpression may contributehuman primary monocytesvirus infected cellsdata also suggestinfected cellsinflammasome activationnk cellsprimary cellsmay protectdata demonstratealso depleteddouble nkviral transmissionone handmutant unablefully restoredexpression increasesexposing macaquesencoded p8dual rolecritical roleantibody titersanimals exposed
