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Immune response landscapes for the PAE/B/alum and PC/MF59 regimens.

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posted on 30.01.2020 by Lue Ping Zhao, Andrew Fiore-Gartland, Lindsay N. Carpp, Kristen W. Cohen, Nadine Rouphael, Llewellyn Fleurs, One Dintwe, Michael Zhao, Zoe Moodie, Youyi Fong, Nigel Garrett, Ying Huang, Craig Innes, Holly E. Janes, Erica Lazarus, Nelson L. Michael, Sorachai Nitayaphan, Punnee Pitisuttithum, Supachai Rerks-Ngarm, Merlin L. Robb, Stephen C. De Rosa, Lawrence Corey, Glenda E. Gray, Kelly E. Seaton, Nicole L. Yates, M. Juliana McElrath, Nicole Frahm, Georgia D. Tomaras, Peter B. Gilbert

A) Heatmap of the same 29 immune response measurements combining RV144 and HVTN 097 vaccine recipients (pooled) and HVTN 100 vaccine recipients. Columns designate immune responses; cluster, response, gene, and clade information are given in the top 4 color-coded bars. Rows designate participants; cluster and study information are given in the two color-coded bars on the left. Dendrograms on the top and left illustrate column and participant clustering, respectively. Immune response measurement values are designated by color according to the key shown in the upper left. Scatterplots of participant-specific average values of CD4+ T-cell and anti-V1V2 antibody responses in (B) RV144 and HVTN 097 and (C) HVTN 100. Ellipsoids of bivariate normal distributions, based on respective empirical means and co-variances, are used to approximately cover 90% empirical bivariate observations. Panels B and C are shown on BDPT-transformed scales.

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