Immune dynamics throughout the experiment.

(A) ELISA: Specific humoral immune response in relative optical density units in TB ELISA. * Comparison between MdR-FD and Control (p = 0.0007) and MdR-RD (<0.0001) groups at day 78. ** Comparison between MdR-FD and Control (p = 0.0239) and MdR-RD (p<0.0110) groups at day 186. Other days differences are not statistically significant at p<0.0500. (B) IFN: Specific cellular immune response in optical density units in Interferon γ release assay. * Comparison between MdR-FD and Control (p = 0.0061) and MdR-RD (p = 0.0051) groups at day 15. ** Comparison between MdR-FD and Control (p = 0.0003) and MdR-RD (<0.0110) groups at day 43. *** Comparison between MdR-FD and Control (p = 0.0190) and MdR-RD (p = 0.0580) groups at day 78. **** Comparison between MdR-FD and Control (p = 0.0043) and MdR-RD (p<0.0001) groups at day 186. Other days differences are not statistically significant at p<0.0500. (C) Skin test: Mean group skin test results in mm. * Comparison between Control and MdR-FD (p<0.0001) or MdR-RD (p = 0.9678) and between both MdR groups (p<0.0001) at day 43. ** Comparison between Control and MdR-FD (p<0.0001) or MdR-RD (p = 0.5456) and between both both MdR groups (p<0.0001) at day 78. Control: Untreated control group. MdR-FD: Full-dose group. MdR-RD: Reduced-dose group.