Identification of key overlapping genes in ALI.

<p>(A) Volcano plot depicting the results of differential gene expression analysis. Red dots represent up-regulated DEGs, and blue dots represent down-regulated DEGs. (B) Venn diagram of cross-analysis of up-regulated DEGs, down-regulated DEGs, and turquoise modules of the GSE263867 dataset to obtain overlapping genes. (C-E) PPI network analysis of overlapping genes, including MCC, MNC, and degree. Nodes represent proteins or protein domains, while edges represent interactions between these proteins. (F) This Venn diagram cross-analyzes three PPI modules, identifying five key overlapping genes. (G) Expression analysis of five key overlapping genes in control and case groups of the GSE263867 dataset. Red represents the case group, and blue represents the control group. ALI, Acute lung injury; DEGs, Differential Expressed Genes; PPI, protein-protein interactions; MCC, Maximal Clique Centrality; MNC, Maximal Neighborhood Component. *<i>p</i><0.05, **<i>p</i><0.01, ***<i>p</i><0.001.</p>