ITH of molecular pathways.

(A) Barplot with quantification of number of genes with high ITH-score (STD > 0.5) for each tumor and all tumors combined. * denotes tumors with the highest amount of high ITH-score genes, which are included in B-D. (B) Subtyping results for each biopsy from tumor P13 and P05. (C-D) Tumor-specific network maps for two tumors illustrating the 5000 ssGSEA terms with the highest ITH for tumor P13 in (C) and tumor P05 in (D). Yellow dots/font indicates mechanisms that are upregulated in the sample compared to the other samples from the same tumor, while blue indicates downregulated mechanisms.