pgen.1007059.g004.tif (143.87 kB)

IR56d neurons are selectively responsive to short and medium-chain FAs.

Download (143.87 kB)
figure
posted on 09.11.2017 by John M. Tauber, Elizabeth B. Brown, Yuanyuan Li, Maria E. Yurgel, Pavel Masek, Alex C. Keene

(A) PER in response to short-chain pentanoic acid (PeA, n = 46), medium-chain octanoic acid (OcA, n = 26), and long-chain oleic acid (n = 46) in TNT and control impTNT flies. Blocking synaptic release in IR56d neurons with TNT significantly decreases PER to octanoic acid (n = 29), but does not affect PER for pentanoic (n = 42) or oleic acid (n = 42). Wilcoxon Rank-Sum Test; ***p<0.001. (B) Average peak %ΔF/F for the posterior projections of IR56d neurons in response to water, 1% DMSO, pentanoic acid, octanoic acid, and oleic acid (n = 9, 8, 9, 9, 8, respectively), and (C) the anterior projections (n = 9, 7, 9, 9, 7, respectively). Error bars indicate SEM. One-way ANOVA with Tukey’s HSD; ***p<0.001.

History

Licence

Exports