pone.0198089.g003.tif (519.27 kB)

IMM correlates with hind limb muscle weight in SOD1G93A mice as disease progresses.

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posted on 2018-05-29, 17:35 authored by Laura Pasetto, Davide Olivari, Giovanni Nardo, Maria Chiara Trolese, Caterina Bendotti, Rosanna Piccirillo, Valentina Bonetto

(A) IMM was evaluated in Ntg and longitudinally in SOD1G93A mice at 12, 14, 17 and 20 weeks of age (n = 5 for each group). Decrease in % was reported respect to Ntg mice at 12 weeks of age. Data, expressed as mean ± SEM, were statistically significant different (p < 0.05), by one-way ANOVA, Newman-Keuls post-hoc test: *, versus Ntg; #, versus 12-week old SOD1G93A mice. (B-C) A correlation analysis was done with the mean values of the IMM and of the muscle weight of TA (B) and Gastrocnemius (GC) (C) for the different experimental groups. The analysis confirmed a significant (p < 0.008 for TA, p < 0.005 for GC) direct correlation between the two type of measurements with r2 = 0.9293 and r2 = 0.9502 for TA and GC respectively. Data are expressed as mean ± SEM.